Being constantly surrounded by microorganisms plants developed extracellular surface receptors, to recognize pathogen-associated molecular patterns (PAMPs). Perception of a microorganism PAMPs at the cell surface initiates dynamics signaling pathways that regulate plant responses to pathogens. Central in this signaling is protein association-related reversible protein phosphorylation performed by protein kinases and opposing protein phosphatases. These phosphorylation events lead to specific stress-induced gene expressions, accumulation of plant hormones, and presumably also other metabolites. This proposal aims to extend the knowledge on the level at and down stream of PAMP signal perception. This includes regulation of protein phosphorylation, identification of target genes and complex protein associations as well as plant cell responses by metabolic changes. Through establishing synergies and rapid integration of the best practices elaborated in different labs we aim to fill the gaps and provide a sound basis for experimental joint activities. This research will generate the outcome enabling translation of gained knowledge from innovative basic research into agricultural and economic benefits, such as sustainable plant cultivation.